Build your own fiction quadrant

I found this note in Bianca Aguilar's Digital Garden:

The alternative is to build your own quadrant. To find two axes that have been overlooked. To build a story, a true story, that keeps your promise, that puts you in a position where you are the clear and obvious choice.

The interesting thing about this is that it could be applied to fiction writing as well.

Explore genres and subgenres and find two axes that interest you but haven't been intersected. Build on it. Make it rhyme.